Cytomegalovirus cell tropism

C Sinzger, M Digel, G Jahn - Human cytomegalovirus, 2008 - Springer
C Sinzger, M Digel, G Jahn
Human cytomegalovirus, 2008Springer
The human cytomegalovirus (HCMV) can infect a remarkably broad cell range within its
host, including parenchymal cells and connective tissue cells of virtually any organ and
various hematopoietic cell types. Epithelial cells, endothelial cells, fibroblasts and smooth
muscle cells are the predominant targets for virus replication. The pathogenesis of acute
HCMV infections is greatly influenced by this broad target cell range. Infection of epithelial
cells presumably contributes to interhost transmission. Infection of endothelial cells and …
Abstract
The human cytomegalovirus (HCMV) can infect a remarkably broad cell range within its host, including parenchymal cells and connective tissue cells of virtually any organ and various hematopoietic cell types. Epithelial cells, endothelial cells, fibroblasts and smooth muscle cells are the predominant targets for virus replication. The pathogenesis of acute HCMV infections is greatly influenced by this broad target cell range. Infection of epithelial cells presumably contributes to interhost transmission. Infection of endothelial cells and hematopoietic cells facilitates systemic spread within the host. Infection of ubiquitous cell types such as fibroblasts and smooth muscle cells provides the platform for efficient proliferation of the virus.
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