Peripheral AMPA receptors contribute to muscle nociception and c-fos activation
YH Chun, D Frank, JS Lee, Y Zhang, QS Auh… - Neuroscience …, 2008 - Elsevier
In this study, involvement of peripheral AMPA receptors in mediating craniofacial muscle
pain was investigated. AMPA receptor subunits, GluR1 and GluR2, were predominantly
expressed in small to medium size neurons but more GluR2 positive labeling were
encountered in trigeminal ganglia (TG) of male Sprague Dawley rats. A greater prevalence
of GluR2 is reflected by the significantly higher percentage of GluR2 than GluR1 positive
masseter afferents. Nocifensive behavior and c-fos immunoreactivity were assessed from …
pain was investigated. AMPA receptor subunits, GluR1 and GluR2, were predominantly
expressed in small to medium size neurons but more GluR2 positive labeling were
encountered in trigeminal ganglia (TG) of male Sprague Dawley rats. A greater prevalence
of GluR2 is reflected by the significantly higher percentage of GluR2 than GluR1 positive
masseter afferents. Nocifensive behavior and c-fos immunoreactivity were assessed from …