Growth hormone reverses nonalcoholic steatohepatitis in a patient with adult growth hormone deficiency

Y Takahashi, K Iida, K Takahashi, S Yoshioka… - Gastroenterology, 2007 - Elsevier
Y Takahashi, K Iida, K Takahashi, S Yoshioka, H Fukuoka, R Takeno, M Imanaka…
Gastroenterology, 2007Elsevier
Background & Aims: Nonalcoholic steatohepatitis (NASH) is an emerging progressive
hepatic disease and demonstrates steatosis, inflammation, and fibrosis. Insulin resistance is
a common feature in the development of NASH. Molecular pathogenesis of NASH consists
of 2 steps: triglyceride accumulation in hepatocytes with insulin resistance and an enhanced
oxidative stress caused by reactive oxygen species. Interestingly, NASH demonstrates a
striking similarity to the pathologic conditions observed in adult growth hormone deficiency …
Background & Aims
Nonalcoholic steatohepatitis (NASH) is an emerging progressive hepatic disease and demonstrates steatosis, inflammation, and fibrosis. Insulin resistance is a common feature in the development of NASH. Molecular pathogenesis of NASH consists of 2 steps: triglyceride accumulation in hepatocytes with insulin resistance and an enhanced oxidative stress caused by reactive oxygen species. Interestingly, NASH demonstrates a striking similarity to the pathologic conditions observed in adult growth hormone deficiency (AGHD). AGHD is characterized by decreased lean body mass, increased visceral adiposity, abnormal lipid profile, and insulin resistance. Moreover, liver dysfunctions with hyperlipidemia and nonalcoholic fatty liver disease (NAFLD) are frequently observed in patients with AGHD, and it is accompanied by metabolic syndrome.
Methods
We studied a case diagnosed as NASH with hyperlipidemia in AGHD. The effect of GH-replacement therapy on the patient was analyzed.
Results
Six months of GH-replacement therapy in the patient drastically ameliorated NASH and the abnormal lipid profile concomitant with a marked reduction in oxidative stress.
Conclusions
These results suggest that GH plays an essential role in the metabolic and redox regulation in the liver.
Elsevier