[HTML][HTML] Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin …
CS Choi, DB Savage, A Kulkarni, XX Yu, ZX Liu… - Journal of Biological …, 2007 - ASBMB
Nonalcoholic fatty liver disease (NAFLD) is a major contributing factor to hepatic insulin
resistance in type 2 diabetes. Diacylglycerol acyltransferase (Dgat), of which there are two
isoforms (Dgat1 and Dgat2), catalyzes the final step in triglyceride synthesis. We evaluated
the metabolic impact of pharmacological reduction of DGAT1 and-2 expression in liver and
fat using antisense oligonucleotides (ASOs) in rats with diet-induced NAFLD. Dgat1 and
Dgat2 ASO treatment selectively reduced DGAT1 and DGAT2 mRNA levels in liver and fat …
resistance in type 2 diabetes. Diacylglycerol acyltransferase (Dgat), of which there are two
isoforms (Dgat1 and Dgat2), catalyzes the final step in triglyceride synthesis. We evaluated
the metabolic impact of pharmacological reduction of DGAT1 and-2 expression in liver and
fat using antisense oligonucleotides (ASOs) in rats with diet-induced NAFLD. Dgat1 and
Dgat2 ASO treatment selectively reduced DGAT1 and DGAT2 mRNA levels in liver and fat …