Mechanisms of nitrite reduction to nitric oxide in the heart and vessel wall
JL Zweier, H Li, A Samouilov, X Liu - Nitric oxide, 2010 - Elsevier
Nitric oxide (NO) is an important regulator of a variety of biological functions, and also has a
role in the pathogenesis of cellular injury. It had been generally accepted that NO is solely
generated in biological tissues by specific nitric oxide synthases (NOS) which metabolize
arginine to citrulline with the formation of NO. However, over the last 15years, nitrite-
mediated NO production has been shown to be an important mechanism of NO formation in
the heart and cardiovascular system. Now numerous studies have demonstrated that nitrite …
role in the pathogenesis of cellular injury. It had been generally accepted that NO is solely
generated in biological tissues by specific nitric oxide synthases (NOS) which metabolize
arginine to citrulline with the formation of NO. However, over the last 15years, nitrite-
mediated NO production has been shown to be an important mechanism of NO formation in
the heart and cardiovascular system. Now numerous studies have demonstrated that nitrite …