[HTML][HTML] Tissue processing of nitrite in hypoxia: an intricate interplay of nitric oxide-generating and-scavenging systems
M Feelisch, BO Fernandez, NS Bryan… - Journal of Biological …, 2008 - ASBMB
Although nitrite (NO 2-) and nitrate (NO 3-) have been considered traditionally inert
byproducts of nitric oxide (NO) metabolism, recent studies indicate that NO 2-represents an
important source of NO for processes ranging from angiogenesis through hypoxic
vasodilation to ischemic organ protection. Despite intense investigation, the mechanisms
through which NO 2-exerts its physiological/pharmacological effects remain incompletely
understood. We sought to systematically investigate the fate of NO 2-in hypoxia from cellular …
byproducts of nitric oxide (NO) metabolism, recent studies indicate that NO 2-represents an
important source of NO for processes ranging from angiogenesis through hypoxic
vasodilation to ischemic organ protection. Despite intense investigation, the mechanisms
through which NO 2-exerts its physiological/pharmacological effects remain incompletely
understood. We sought to systematically investigate the fate of NO 2-in hypoxia from cellular …