[HTML][HTML] JUN oncogene amplification and overexpression block adipocytic differentiation in highly aggressive sarcomas

O Mariani, C Brennetot, JM Coindre, N Gruel, C Ganem… - Cancer cell, 2007 - cell.com
O Mariani, C Brennetot, JM Coindre, N Gruel, C Ganem, O Delattre, MH Stern, A Aurias
Cancer cell, 2007cell.com
The human oncogene JUN encodes a component of the AP-1 complex and is consequently
involved in a wide range of pivotal cellular processes, including cell proliferation,
transformation, and apoptosis. Nevertheless, despite extensive analyses of its functions, it
has never been directly involved in a human cancer. We demonstrate here that it is highly
amplified and overexpressed in undifferentiated and aggressive human sarcomas, which
are blocked at an early step of adipocyte differentiation. We confirm by cellular and xenograft …
Summary
The human oncogene JUN encodes a component of the AP-1 complex and is consequently involved in a wide range of pivotal cellular processes, including cell proliferation, transformation, and apoptosis. Nevertheless, despite extensive analyses of its functions, it has never been directly involved in a human cancer. We demonstrate here that it is highly amplified and overexpressed in undifferentiated and aggressive human sarcomas, which are blocked at an early step of adipocyte differentiation. We confirm by cellular and xenograft mouse models recapitulating these sarcoma genetics that the failure to differentiate is dependent upon JUN amplification/overexpression.
cell.com