[HTML][HTML] The regulation of AP-1 activity by mitogen-activated protein kinases
M Karin - Journal of Biological Chemistry, 1995 - ASBMB
AP-1 is a sequence-specific transcriptional activator composed of members of the Jun and
Fos families (for review see Ref. 1). These proteins, which belong to the bZIP group of DNA
binding proteins (for review see Ref. 2), associate to form a variety of homo-and
heterodimers that bind to a common site (1). First identified by its role in human
metallothionein IIA gene regulation (3), AP-1 was also found as a transcription factor that
mediates gene induction by the phorbol ester tumor promoter 12-0-tetradecanoylphorbol-13 …
Fos families (for review see Ref. 1). These proteins, which belong to the bZIP group of DNA
binding proteins (for review see Ref. 2), associate to form a variety of homo-and
heterodimers that bind to a common site (1). First identified by its role in human
metallothionein IIA gene regulation (3), AP-1 was also found as a transcription factor that
mediates gene induction by the phorbol ester tumor promoter 12-0-tetradecanoylphorbol-13 …