Novel cerebral lesions in the Eker rat model of tuberous sclerosis: cortical tuber and anaplastic ganglioglioma
M Mizuguchi, S Takashima… - … of Neuropathology & …, 2000 - academic.oup.com
M Mizuguchi, S Takashima, H Yamanouchi, Y Nakazato, H Mitani, O Hino
Journal of Neuropathology & Experimental Neurology, 2000•academic.oup.comThe Eker rat is a model for human tuberous sclerosis (TSC) caused by a mutation in the
Tsc2 gene. We describe here histological and immunohistochemical findings of the brain
lesions in Eker rats, with emphasis on 2 novel lesions found in this study: a cortical tuber and
an anaplastic ganglioglioma. The rat cortical tuber resembled those of humans, and further
confirmed the value of this animal model as a tool for investigating the molecular pathology
of tuberous sclerosis. On the other hand, the rat anaplastic ganglioglioma had features of a …
Tsc2 gene. We describe here histological and immunohistochemical findings of the brain
lesions in Eker rats, with emphasis on 2 novel lesions found in this study: a cortical tuber and
an anaplastic ganglioglioma. The rat cortical tuber resembled those of humans, and further
confirmed the value of this animal model as a tool for investigating the molecular pathology
of tuberous sclerosis. On the other hand, the rat anaplastic ganglioglioma had features of a …
Abstract
The Eker rat is a model for human tuberous sclerosis (TSC) caused by a mutation in the Tsc2 gene. We describe here histological and immunohistochemical findings of the brain lesions in Eker rats, with emphasis on 2 novel lesions found in this study: a cortical tuber and an anaplastic ganglioglioma. The rat cortical tuber resembled those of humans, and further confirmed the value of this animal model as a tool for investigating the molecular pathology of tuberous sclerosis. On the other hand, the rat anaplastic ganglioglioma had features of a malignant neoplasm that are absent from human subependymal giant cell astrocytomas.
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