Species-and age-dependent changes in the relative amounts of cardiac myosin isoenzymes in mammals
AM Lompre, JJ Mercadier, C Wisnewsky… - Developmental …, 1981 - Elsevier
AM Lompre, JJ Mercadier, C Wisnewsky, P Bouveret, C Pantaloni, A d'Albis, K Schwartz
Developmental biology, 1981•ElsevierIn mice, rabbits, and pigs, two basic types of cardiac myosin isoenzymes were found by
electrophoresis of native molecules: a fast-migrating form with high Ca 2+-dependent
ATPase activity and a slow-migrating form with low activity. According to the nomenclature of
JFY Hoh, PA McGrath, and PT Hale (1978, J. Mol. Cell. Cardiol. 10, 1053–1076) these forms
are called, respectively, V1 and V3. In all species, myosin was essentially V3 during fetal life,
while V1 appeared around the time of birth. There were species differences in adults: mice …
electrophoresis of native molecules: a fast-migrating form with high Ca 2+-dependent
ATPase activity and a slow-migrating form with low activity. According to the nomenclature of
JFY Hoh, PA McGrath, and PT Hale (1978, J. Mol. Cell. Cardiol. 10, 1053–1076) these forms
are called, respectively, V1 and V3. In all species, myosin was essentially V3 during fetal life,
while V1 appeared around the time of birth. There were species differences in adults: mice …
Abstract
In mice, rabbits, and pigs, two basic types of cardiac myosin isoenzymes were found by electrophoresis of native molecules: a fast-migrating form with high Ca2+-dependent ATPase activity and a slow-migrating form with low activity. According to the nomenclature of J. F. Y. Hoh, P. A. McGrath, and P. T. Hale (1978, J. Mol. Cell. Cardiol. 10, 1053–1076) these forms are called, respectively, V1 and V3. In all species, myosin was essentially V3 during fetal life, while V1 appeared around the time of birth. There were species differences in adults: mice remained V1, while rabbits and pigs returned to V3 after 3 weeks of age. Adult dog, beef, and human myosins were also composed of the V3 form only.
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