[HTML][HTML] CDKN1C negatively regulates RNA polymerase II C-terminal domain phosphorylation in an E2F1-dependent manner
Y Ma, L Chen, GM Wright, SR Pillai… - Journal of biological …, 2010 - ASBMB
CDKN1C is a cyclin-dependent kinase inhibitor and is a candidate tumor suppressor gene.
We previously found that the CDKN1C protein represses E2F1-driven transcription in an
apparent negative feedback loop. Herein, we explore the mechanism by which CDKN1C
represses transcription. We find that adenoviral-mediated overexpression of CDKN1C leads
to a dramatic reduction in phosphorylation of the RNA polymerase II (pol II) C-terminal
domain (CTD). RNA interference studies demonstrate that this activity is not an artifact of …
We previously found that the CDKN1C protein represses E2F1-driven transcription in an
apparent negative feedback loop. Herein, we explore the mechanism by which CDKN1C
represses transcription. We find that adenoviral-mediated overexpression of CDKN1C leads
to a dramatic reduction in phosphorylation of the RNA polymerase II (pol II) C-terminal
domain (CTD). RNA interference studies demonstrate that this activity is not an artifact of …