[HTML][HTML] Human cellular restriction factors that target HIV-1 replication
K Strebel, J Luban, KT Jeang - BMC medicine, 2009 - Springer
K Strebel, J Luban, KT Jeang
BMC medicine, 2009•SpringerRecent findings have highlighted roles played by innate cellular factors in restricting
intracellular viral replication. In this review, we discuss in brief the activities of apolipoprotein
B mRNA-editing enzyme 3G (APOBEC3G), bone marrow stromal cell antigen 2 (BST-2),
cyclophilin A, tripartite motif protein 5 alpha (Trim5α), and cellular microRNAs as examples
of host restriction factors that target HIV-1. We point to countermeasures encoded by HIV-1
for moderating the potency of these cellular restriction functions.
intracellular viral replication. In this review, we discuss in brief the activities of apolipoprotein
B mRNA-editing enzyme 3G (APOBEC3G), bone marrow stromal cell antigen 2 (BST-2),
cyclophilin A, tripartite motif protein 5 alpha (Trim5α), and cellular microRNAs as examples
of host restriction factors that target HIV-1. We point to countermeasures encoded by HIV-1
for moderating the potency of these cellular restriction functions.
Abstract
Recent findings have highlighted roles played by innate cellular factors in restricting intracellular viral replication. In this review, we discuss in brief the activities of apolipoprotein B mRNA-editing enzyme 3G (APOBEC3G), bone marrow stromal cell antigen 2 (BST-2), cyclophilin A, tripartite motif protein 5 alpha (Trim5α), and cellular microRNAs as examples of host restriction factors that target HIV-1. We point to countermeasures encoded by HIV-1 for moderating the potency of these cellular restriction functions.
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