The acute effect of metformin on glucose production in the conscious dog is primarily attributable to inhibition of glycogenolysis
CA Chu, N Wiernsperger, N Muscato… - Metabolism …, 2000 - metabolismjournal.com
Although metformin has been used worldwide to treat type 2 diabetes for several decades,
its mechanism of action on glucose homeostasis remains controversial. To further assess
the effect of metformin on glucose metabolism, 10 42-hour-fasted conscious dogs were
studied in the absence ([Con] n= 5) and presence ([Met] n= 5) of a portal infusion of
metformin (0.15 mg· kg− 1· min− 1) over 300 minutes. Hepatic glucose production was
measured by both arteriovenous-difference and tracer methods. All dogs were maintained …
its mechanism of action on glucose homeostasis remains controversial. To further assess
the effect of metformin on glucose metabolism, 10 42-hour-fasted conscious dogs were
studied in the absence ([Con] n= 5) and presence ([Met] n= 5) of a portal infusion of
metformin (0.15 mg· kg− 1· min− 1) over 300 minutes. Hepatic glucose production was
measured by both arteriovenous-difference and tracer methods. All dogs were maintained …