Cell wall lipids from Mycobacterium bovis BCG are inflammatory when inoculated within a gel matrix: characterization of a new model of the granulomatous response …
ER Rhoades, RE Geisel, BA Butcher, S McDonough… - Tuberculosis, 2005 - Elsevier
The chronic inflammatory response to Mycobacterium generates complex granulomatous
lesions that balance containment with destruction of infected tissues. To study the
contributing factors from host and pathogen, we developed a model wherein defined
mycobacterial components and leukocytes are delivered in a gel, eliciting a localized
response that can be retrieved and analysed. We validated the model by comparing
responses to the cell wall lipids from Mycobacterium bovis bacillus Calmette–Guérin (BCG) …
lesions that balance containment with destruction of infected tissues. To study the
contributing factors from host and pathogen, we developed a model wherein defined
mycobacterial components and leukocytes are delivered in a gel, eliciting a localized
response that can be retrieved and analysed. We validated the model by comparing
responses to the cell wall lipids from Mycobacterium bovis bacillus Calmette–Guérin (BCG) …