Effects of dietary nitrate on blood pressure in healthy volunteers
FJ Larsen, B Ekblom, K Sahlin… - … England Journal of …, 2006 - Mass Medical Soc
FJ Larsen, B Ekblom, K Sahlin, JO Lundberg, E Weitzberg
New England Journal of Medicine, 2006•Mass Medical SocTo the Editor: Nitric oxide, generated by nitric oxide synthase, is a key regulator of vascular
integrity. This system is dysfunctional in many cardiovascular disorders, including
hypertension. A fundamentally different pathway for the generation of nitric oxide was
recently described in which the anions nitrate (NO3–) and nitrite (NO2–) are converted into
nitric oxide and other bioactive nitrogen oxides. 1–3 Nitrate is abundant in our diet, and
particularly high levels are found in many vegetables. 3 We examined the effect of 3-day …
integrity. This system is dysfunctional in many cardiovascular disorders, including
hypertension. A fundamentally different pathway for the generation of nitric oxide was
recently described in which the anions nitrate (NO3–) and nitrite (NO2–) are converted into
nitric oxide and other bioactive nitrogen oxides. 1–3 Nitrate is abundant in our diet, and
particularly high levels are found in many vegetables. 3 We examined the effect of 3-day …
To the Editor: Nitric oxide, generated by nitric oxide synthase, is a key regulator of vascular integrity. This system is dysfunctional in many cardiovascular disorders, including hypertension. A fundamentally different pathway for the generation of nitric oxide was recently described in which the anions nitrate (NO3–) and nitrite (NO2–) are converted into nitric oxide and other bioactive nitrogen oxides.1–3 Nitrate is abundant in our diet, and particularly high levels are found in many vegetables.3
We examined the effect of 3-day dietary supplementation with either sodium nitrate (at a dose of 0.1 mmol per kilogram of . . .
The New England Journal Of Medicine