[HTML][HTML] High telomerase activity and long telomeres in advanced hepatocellular carcinomas with poor prognosis

BK Oh, H Kim, YN Park, JE Yoo, J Choi, KS Kim… - Laboratory …, 2008 - Elsevier
Telomerase reactivation and telomere maintenance are crucial in carcinogenesis and tumor
progression. In this study, the relationships between telomere parameters, chromosomal
instability and clinicopathological features were evaluated in hepatocellular carcinomas
(HCCs). Telomere length (TL), telomerase activity (TA) and human telomerase reverse
transcriptase (hTERT) mRNA levels were measured in 49 hepatitis B virus (HBV)-related
HCCs and corresponding non-tumorous tissues. The results were compared with …