Three discrete areas within the chromosomal 8p21. 3–23 region are associated with the development of breast carcinoma of Indian patients
N Bhattacharya, N Chunder, D Basu, A Roy… - … and molecular pathology, 2004 - Elsevier
Deletion in the 22.9-Mb chromosomal (chr.) 8p21. 3–23 region has been shown to be
necessary for the development of breast carcinoma (CaBr). In this study, we have attempted
to detect the minimal deleted region (s) in the chr. 8p21. 3–23 region in 62 primary breast
lesions having 56 CaBr tumors and six other breast lesions of Indian patients using 15
microsatellite markers. The loss of heterozygosity (LOH) was observed for at least one
marker in 96.4%(54/56) of the CaBr samples. Three discrete minimal deleted regions with …
necessary for the development of breast carcinoma (CaBr). In this study, we have attempted
to detect the minimal deleted region (s) in the chr. 8p21. 3–23 region in 62 primary breast
lesions having 56 CaBr tumors and six other breast lesions of Indian patients using 15
microsatellite markers. The loss of heterozygosity (LOH) was observed for at least one
marker in 96.4%(54/56) of the CaBr samples. Three discrete minimal deleted regions with …