Effects of the deregulated expression of human interleukin-2 in transgenic mice
Y Ishida, M Nishi, O Taguchl, K Inaba… - International …, 1989 - academic.oup.com
Y Ishida, M Nishi, O Taguchl, K Inaba, N Minato, M Kawaichi, T Honjo
International Immunology, 1989•academic.oup.comWe constructed transgenic mice that carry the cDNA of human interleukin-2 (IL-2) under the
control of the H-2Kd promoter. The IL-2 transgenic mice expressed human IL-2 mRNA in the
thymus, spleen, bone marrow, lung, muscle and skin. Human IL-2 protein was also detected
in their sera. The IL-2 transgenic mice suffered from alopecia and pneumonia, but no typical
autoimmune reactions seemed to be involved in these lesions. In the epidermis of the IL-2
transgenic mice there was an increase in Thy-1+ dendritic epidermal cells (DEC), which …
control of the H-2Kd promoter. The IL-2 transgenic mice expressed human IL-2 mRNA in the
thymus, spleen, bone marrow, lung, muscle and skin. Human IL-2 protein was also detected
in their sera. The IL-2 transgenic mice suffered from alopecia and pneumonia, but no typical
autoimmune reactions seemed to be involved in these lesions. In the epidermis of the IL-2
transgenic mice there was an increase in Thy-1+ dendritic epidermal cells (DEC), which …
Abstract
We constructed transgenic mice that carry the cDNA of human interleukin-2 (IL-2) under the control of the H-2Kd promoter. The IL-2 transgenic mice expressed human IL-2 mRNA in the thymus, spleen, bone marrow, lung, muscle and skin. Human IL-2 protein was also detected in their sera. The IL-2 transgenic mice suffered from alopecia and pneumonia, but no typical autoimmune reactions seemed to be involved in these lesions. In the epidermis of the IL-2 transgenic mice there was an increase in Thy-1+ dendritic epidermal cells (DEC), which might be involved in the skin lesion. Immune responses of their spleen cells against antigens were significantly impaired whereas their spleen cells responded well to polyclonal lymphocyte activators.
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