Fatal leukemia in interleukin-15 transgenic mice
TA Fehniger, K Suzuki, JB VanDeusen… - Blood Cells, Molecules …, 2001 - Elsevier
The role of inflammation in the early genesis of certain malignancies has recently been
appreciated. Interleukin (IL)-15, a proinflammatory cytokine and growth factor, is required for
lymphocyte homeostasis. Intriguingly, the expression of IL-15 protein is tightly controlled by
multiple posttranscriptional mechanisms, suggesting that inappropriate expression of IL-15
may be detrimental to the host. We recently engineered a transgenic mouse in which the
normal posttranscriptional control of IL-15 is eliminated, thereby overexpressing the murine …
appreciated. Interleukin (IL)-15, a proinflammatory cytokine and growth factor, is required for
lymphocyte homeostasis. Intriguingly, the expression of IL-15 protein is tightly controlled by
multiple posttranscriptional mechanisms, suggesting that inappropriate expression of IL-15
may be detrimental to the host. We recently engineered a transgenic mouse in which the
normal posttranscriptional control of IL-15 is eliminated, thereby overexpressing the murine …