A quantitative study of the localization of atherosclerotic lesions in the rabbit aorta

JF Cornhill, MR Roach - Atherosclerosis, 1976 - Elsevier
A quantitative study of the size and location of early sudanophilic lesions has been carried
out on the aortae of five rabbits. The atherosclerotic lesions were induced by feeding an
average of 114 (±3.7) egg yolks over an average period of 83 (±1.7) days. The aortic lesions
were visualized by gross staining with Sudan III and measured by the polar coordinate
method. The lesions were almost entirely around orifices; their size was directly proportional
to the area of the associated ostium (P< 0.005). The sudanophilic deposits were located …