[HTML][HTML] Mixed chimerism following in utero hematopoietic stem cell transplantation in murine models of hemoglobinopathy
S Hayashi, O Abdulmalik, WH Peranteau… - Experimental …, 2003 - Elsevier
OBJECTIVE: Mixed hematopoietic chimerism after bone marrow transplantation can provide
effective treatment for β-thalassemia because of the selective advantage that exists for donor
erythropoiesis. In utero hematopoietic stem cell transplantation (IUHSCTx) can achieve
mixed hematopoietic chimerism, particularly when a selective advantage exists for donor
cells. To investigate the biology of IUHSCTx in hemoglobinopathies, we performed fully
allogeneic IUHSCTx in murine models of β-thalassemia (Thal) and sickle cell disease …
effective treatment for β-thalassemia because of the selective advantage that exists for donor
erythropoiesis. In utero hematopoietic stem cell transplantation (IUHSCTx) can achieve
mixed hematopoietic chimerism, particularly when a selective advantage exists for donor
cells. To investigate the biology of IUHSCTx in hemoglobinopathies, we performed fully
allogeneic IUHSCTx in murine models of β-thalassemia (Thal) and sickle cell disease …