Donor major histocompatibility complex class I expression determines the outcome of prenatal transplantation

ET Durkin, KA Jones, D Elnaggar… - Journal of pediatric surgery, 2008 - Elsevier
PURPOSE: The failure of in utero transplantation in immune-competent recipients suggests
the existence of a fetal immune barrier. The importance of donor major histocompatibility
complex (MHC) class I expression in the induction of prenatal tolerance remains undefined.
We hypothesized that donor cell MHC class I expression facilitates engraftment in prenatal
allogeneic recipients rather than promoting immune rejection. METHODS: B6. Ly5. 2 (class
I+) or B6. TAP−/−(class I−) murine fetal liver cells were transplanted into age-matched …