ContextThroughout the past 40 years, a vast and sometimes contradictory literature has
accumulated regarding hypertrophic cardiomyopathy (HCM), a genetic cardiac disease
caused by a variety of mutations in genes encoding sarcomeric proteins and characterized
by a broad and expanding clinical spectrum. ObjectivesTo clarify and summarize the
relevant clinical issues and to profile rapidly evolving concepts regarding HCM. Data
SourcesSystematic analysis of the relevant HCM literature, accessed through MEDLINE …