Escherichia coli isolated from a Crohn's disease patient adheres, invades, and induces inflammatory responses in polarized intestinal epithelial cells
T Eaves-Pyles, CA Allen, J Taormina… - International Journal of …, 2008 - Elsevier
Inflammatory diseases of the intestinal tract are a major health concern both in the United
States and around the world. Evidence now suggests that a new category of Escherichia
coli, designated Adherent Invasive E. coli (AIEC) is highly prevalent in Crohn's Disease (CD)
patients. AIEC strains have been shown to colonize and adhere to intestinal epithelial cells
(IEC). However, the role AIEC strains play in the induction of an inflammatory response is
not known. Therefore, we examined several E. coli strains (designated LF82, O83: H1, 6604 …
States and around the world. Evidence now suggests that a new category of Escherichia
coli, designated Adherent Invasive E. coli (AIEC) is highly prevalent in Crohn's Disease (CD)
patients. AIEC strains have been shown to colonize and adhere to intestinal epithelial cells
(IEC). However, the role AIEC strains play in the induction of an inflammatory response is
not known. Therefore, we examined several E. coli strains (designated LF82, O83: H1, 6604 …