Overload of iron in the skin of patients with varicose ulcers: possible contributing role of iron accumulation in progression of the disease
Z Ackerman, M Seidenbaum, E Loewenthal… - Archives of …, 1988 - jamanetwork.com
• The brown pigmentation of the skin associated with venous ulceration is caused by
increased local iron deposition. Diagnostic x-ray spectrometry, a method based on x-ray
fluorescence analysis, was used for the noninvasive determination of iron levels in the skin
of patients with venous ulceration. The mean (±SEM) iron concentration in the skin around
the venous ulcer was elevated, compared with control values of nonulcerated skin (250±54
vs 128±39 μg) and compared with normal skin from the forearm (250±54 vs 14±2.5 μg) …
increased local iron deposition. Diagnostic x-ray spectrometry, a method based on x-ray
fluorescence analysis, was used for the noninvasive determination of iron levels in the skin
of patients with venous ulceration. The mean (±SEM) iron concentration in the skin around
the venous ulcer was elevated, compared with control values of nonulcerated skin (250±54
vs 128±39 μg) and compared with normal skin from the forearm (250±54 vs 14±2.5 μg) …