Comparative transcriptomal analysis of isogenic Plasmodium falciparum clones of distinct antigenic and adhesive phenotypes
Antigenic variation is a survival mechanism developed by the malaria parasite Plasmodium
falciparum in order to allow for the establishment of a chronic infection. Here we have
studied clonal differences in the transcriptomes of two isogenic P. falciparum clones (3D7S8.
4 and 3D7AH1S2) of distinct adhesive and antigenic phenotypes employing a P. falciparum
70-mer oligonucleotide microarray. Fifteen transcripts were highly differentially expressed
(greater than a 5-fold change) with five transcripts upregulated in 3D7AH1S2 compared to …
falciparum in order to allow for the establishment of a chronic infection. Here we have
studied clonal differences in the transcriptomes of two isogenic P. falciparum clones (3D7S8.
4 and 3D7AH1S2) of distinct adhesive and antigenic phenotypes employing a P. falciparum
70-mer oligonucleotide microarray. Fifteen transcripts were highly differentially expressed
(greater than a 5-fold change) with five transcripts upregulated in 3D7AH1S2 compared to …