[HTML][HTML] Fibroblast growth factor-2 induces translational regulation of Bcl-XL and Bcl-2 via a MEK-dependent pathway: correlation with resistance to etoposide-induced …
The involvement of fibroblast growth factor-2 (FGF-2) in the biology of small cell lung cancer
(SCLC) has not previously been investigated. Here we report that FGF-2 prevented
etoposide-induced apoptosis in H-510 SCLC cells. Phosphatidylinositol 3-kinase/protein
kinase B signaling did not mediate this effect because FGF-2 failed to activate
phosphatidylinositol 3-kinase or protein kinase B. In contrast, the mitogen-activated
extracellularly regulated kinase kinase (MEK) was crucial for this response because its …
(SCLC) has not previously been investigated. Here we report that FGF-2 prevented
etoposide-induced apoptosis in H-510 SCLC cells. Phosphatidylinositol 3-kinase/protein
kinase B signaling did not mediate this effect because FGF-2 failed to activate
phosphatidylinositol 3-kinase or protein kinase B. In contrast, the mitogen-activated
extracellularly regulated kinase kinase (MEK) was crucial for this response because its …