HMG-CoA reductase inhibitors suppress maturation of human dendritic cells: new implications for atherosclerosis
A Yilmaz, C Reiss, O Tantawi, A Weng, C Stumpf… - Atherosclerosis, 2004 - Elsevier
The beneficial effects of statins in atherosclerosis have been partly attributed to their
immunomodulating functions. Dendritic cells (DC), which are “professional” antigen-
presenting cells, were recently detected in atherosclerotic plaques. It is assumed that DC
play a critical role in the immunological processes related to atherosclerosis. Thus, we
investigated the effects of statins on maturation and antigen-presenting function of DC.
Human monocyte-derived DC were incubated with simvastatin or atorvastatin (1–10μM) for …
immunomodulating functions. Dendritic cells (DC), which are “professional” antigen-
presenting cells, were recently detected in atherosclerotic plaques. It is assumed that DC
play a critical role in the immunological processes related to atherosclerosis. Thus, we
investigated the effects of statins on maturation and antigen-presenting function of DC.
Human monocyte-derived DC were incubated with simvastatin or atorvastatin (1–10μM) for …