Mammalian spermatozoa undergo important plasma membrane maturation steps during
epididymal transit. Among these, changes in lipids and cholesterol are of particular interest
as they are necessary for fertilization. However, molecular mechanisms regulating these
transformations inside the epididymis are still poorly understood. Liver X receptors (LXRs),
the nuclear receptors for oxysterols, are of major importance in intracellular cholesterol
homeostasis, and LXR−/−-deficient male mice have already been shown to have reduced …