[HTML][HTML] Genetic profiling of stage I and II colorectal cancer may predict metastatic relapse
F Al-Mulla, AI Behbehani, MS Bitar, G Varadharaj… - Modern Pathology, 2006 - Elsevier
A substantial number of patients with early-stage colorectal cancer relapse from metastatic
disease. Identification of these patients by genetic profiling of their primary tumours may
allow more informed follow-up and tailored administration of adjuvant therapy. Primary
tumours from 70 patients with early-stage and largely microsatellite-stable colorectal cancer
were profiled using metaphase-based comparative genomic hybridization (CGH) and the
aberrations confirmed independently in a subset of patients using microarray-based CGH …
disease. Identification of these patients by genetic profiling of their primary tumours may
allow more informed follow-up and tailored administration of adjuvant therapy. Primary
tumours from 70 patients with early-stage and largely microsatellite-stable colorectal cancer
were profiled using metaphase-based comparative genomic hybridization (CGH) and the
aberrations confirmed independently in a subset of patients using microarray-based CGH …