Identification of carboxypeptidase E and γ-glutamyl hydrolase as biomarkers for pulmonary neuroendocrine tumors by cDNA microarray
P He, L Varticovski, ED Bowman, J Fukuoka, JA Welsh… - Human pathology, 2004 - Elsevier
Pulmonary neuroendocrine tumors vary dramatically in their malignant behavior. Their
classification, based on histological examination, is often difficult. In search of molecular and
prognostic markers for these tumors, we used cDNA microarray analysis of human
transcripts against reference RNA from a well-characterized immortalized bronchial
epithelial cell line, BEAS-2B. Tumor cells were isolated by laser-capture microdissection
from primary tumors of 17 typical carcinoids, small cell lung cancers, and large cell …
classification, based on histological examination, is often difficult. In search of molecular and
prognostic markers for these tumors, we used cDNA microarray analysis of human
transcripts against reference RNA from a well-characterized immortalized bronchial
epithelial cell line, BEAS-2B. Tumor cells were isolated by laser-capture microdissection
from primary tumors of 17 typical carcinoids, small cell lung cancers, and large cell …