A randomized, double-blind, placebo-controlled study of milk oral immunotherapy for cow's milk allergy
JM Skripak, SD Nash, H Rowley, NH Brereton… - Journal of Allergy and …, 2008 - Elsevier
BACKGROUND: Orally administered, food-specific immunotherapy appears effective in
desensitizing and potentially permanently tolerizing allergic individuals. OBJECTIVE: We
sought to determine whether milk oral immunotherapy (OIT) is safe and efficacious in
desensitizing children with cow's milk allergy. METHODS: Twenty children were randomized
to milk or placebo OIT (2: 1 ratio). Dosing included 3 phases: the build-up day (initial dose,
0.4 mg of milk protein; final dose, 50 mg), daily doses with 8 weekly in-office dose increases …
desensitizing and potentially permanently tolerizing allergic individuals. OBJECTIVE: We
sought to determine whether milk oral immunotherapy (OIT) is safe and efficacious in
desensitizing children with cow's milk allergy. METHODS: Twenty children were randomized
to milk or placebo OIT (2: 1 ratio). Dosing included 3 phases: the build-up day (initial dose,
0.4 mg of milk protein; final dose, 50 mg), daily doses with 8 weekly in-office dose increases …