Probiotics and prebiotic galacto-oligosaccharides in the prevention of allergic diseases: a randomized, double-blind, placebo-controlled trial

K Kukkonen, E Savilahti, T Haahtela… - Journal of Allergy and …, 2007 - Elsevier
BACKGROUND: The increase in allergic diseases is attributed to a relative lack of microbial
stimulation of the infantile gut immune system. Probiotics, live health-promoting microbes,
might offer such stimulation. OBJECTIVE: We studied the effect of a mixture of 4 probiotic
bacterial strains along with prebiotic galacto-oligosaccharides in preventing allergic
diseases. METHODS: We randomized 1223 pregnant women carrying high-risk children to
use a probiotic preparation or a placebo for 2 to 4 weeks before delivery. Their infants …