Epicutaneous exposure of protein antigen induces a predominant Th2-like response with high IgE production in mice.
LF Wang, JY Lin, KH Hsieh, RH Lin - Journal of immunology …, 1996 - journals.aai.org
LF Wang, JY Lin, KH Hsieh, RH Lin
Journal of immunology (Baltimore, Md.: 1950), 1996•journals.aai.orgHapten-induced contact hypersensitivity has been well-characterized in humans as well as
in animal models. However, it is not clear whether or not protein Ag can directly sensitize
epicutaneously and induce a primary immune response. We demonstrated in this study, for
the first time, that through epicutaneous exposure protein Ag in the absence of adjuvant
sensitizes animals and induces a predominant Th2-like response. Furthermore, mice
receiving repeated protein Ag sustained elevated levels of specific IgE. This animal model …
in animal models. However, it is not clear whether or not protein Ag can directly sensitize
epicutaneously and induce a primary immune response. We demonstrated in this study, for
the first time, that through epicutaneous exposure protein Ag in the absence of adjuvant
sensitizes animals and induces a predominant Th2-like response. Furthermore, mice
receiving repeated protein Ag sustained elevated levels of specific IgE. This animal model …
Abstract
Hapten-induced contact hypersensitivity has been well-characterized in humans as well as in animal models. However, it is not clear whether or not protein Ag can directly sensitize epicutaneously and induce a primary immune response. We demonstrated in this study, for the first time, that through epicutaneous exposure protein Ag in the absence of adjuvant sensitizes animals and induces a predominant Th2-like response. Furthermore, mice receiving repeated protein Ag sustained elevated levels of specific IgE. This animal model can be used to investigate the molecular mechanism controlling the differential Th1/Th2 development in skin diseases.
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