[HTML][HTML] RhoA prenylation is required for promotion of cell growth and transformation and cytoskeleton organization but not for induction of serum response element …
The importance of post-translational geranylgeranylation of the GTPase RhoA for its ability
to induce cellular proliferation and malignant transformation is not well understood. In this
manuscript we demonstrate that geranylgeranylation is required for the proper cellular
localization of V14RhoA and for its ability to induce actin stress fiber and focal adhesion
formation. Furthermore, V14RhoA geranylgeranylation was also required for suppressing
p21 WAF transcription, promoting cell cycle progression and cellular proliferation. The ability …
to induce cellular proliferation and malignant transformation is not well understood. In this
manuscript we demonstrate that geranylgeranylation is required for the proper cellular
localization of V14RhoA and for its ability to induce actin stress fiber and focal adhesion
formation. Furthermore, V14RhoA geranylgeranylation was also required for suppressing
p21 WAF transcription, promoting cell cycle progression and cellular proliferation. The ability …