[HTML][HTML] Regulation of human β-cell adhesion, motility, and insulin secretion by collagen IV and its receptor α1β1
T Kaido, M Yebra, V Cirulli, AM Montgomery - Journal of Biological …, 2004 - ASBMB
Collagens have been shown to influence the survival and function of cultured β-cells;
however, the utilization and function of individual collagen receptors in β-cells is largely
unknown. The integrin superfamily contains up to five collagen receptors, but we have
determined that α 1 β 1 is the primary receptor utilized by both fetal and adult β-cells.
Cultured β-cells adhered to and migrated on collagen type IV (Col-IV), and these responses
were mediated almost exclusively by α 1 β 1. The migration of cultured β-cells to Col-IV …
however, the utilization and function of individual collagen receptors in β-cells is largely
unknown. The integrin superfamily contains up to five collagen receptors, but we have
determined that α 1 β 1 is the primary receptor utilized by both fetal and adult β-cells.
Cultured β-cells adhered to and migrated on collagen type IV (Col-IV), and these responses
were mediated almost exclusively by α 1 β 1. The migration of cultured β-cells to Col-IV …