TDP43 is a human low molecular weight neurofilament (hNFL) mRNA-binding protein
The human TAR DNA-binding protein (TDP43) colocalizes with ubiquitinated inclusions in
motor neurons in amyotrophic lateral sclerosis (ALS). TDP43 is both a DNA-binding protein
with a nuclear export sequence that interacts with (TG) nTm elements in DNA and an RNA-
binding protein that interacts with (UG) 6–12 motifs in single–stranded RNA. In control motor
neurons, TDP43 was almost exclusively nuclear, whereas in ALS spinal motor neurons,
TDP43 was predominantly localized to the cytosol and not the nucleus. TDP43 was …
motor neurons in amyotrophic lateral sclerosis (ALS). TDP43 is both a DNA-binding protein
with a nuclear export sequence that interacts with (TG) nTm elements in DNA and an RNA-
binding protein that interacts with (UG) 6–12 motifs in single–stranded RNA. In control motor
neurons, TDP43 was almost exclusively nuclear, whereas in ALS spinal motor neurons,
TDP43 was predominantly localized to the cytosol and not the nucleus. TDP43 was …