Characterization of a hyaluronan receptor on rat sinusoidal liver endothelial cells and its functional relationship to scavenger receptors
PAG McCourt, BH Smedsrød, J Melkko… - Hepatology, 1999 - journals.lww.com
Hyaluronan is a widely distributed extracellular component of connective tissue with several
mechanical and cell biological functions. The serum level of hyaluronan is elevated in
rheumatic and liver diseases and in certain malignancies. The major route of hyaluronan
clearance from the blood is via the liver, taken up predominantly by sinusoidal liver
endothelial cells. We have purified a novel hyaluronan binding protein from liver that also
has an affinity for the N-terminal propeptide of type I procollagen, a physiological scavenger …
mechanical and cell biological functions. The serum level of hyaluronan is elevated in
rheumatic and liver diseases and in certain malignancies. The major route of hyaluronan
clearance from the blood is via the liver, taken up predominantly by sinusoidal liver
endothelial cells. We have purified a novel hyaluronan binding protein from liver that also
has an affinity for the N-terminal propeptide of type I procollagen, a physiological scavenger …