Renal expression of fibrotic matrix proteins and of transforming growth factor-β (TGF-β) isoforms in TGF-β transgenic mice
MM MOZES, EP BÖTTINGER, TA JACOT… - Journal of the …, 1999 - journals.lww.com
Renal pathology in mice that are transgenic for the murine albumin enhancer/promoter
linked to a full-length porcine transforming growth factor-β1 (TGF-β1) gene has been
described previously. In these mice, transgene expression is limited to the liver and the
plasma level of TGF-β is increased. The earliest renal pathologic change is
glomerulosclerosis, at 3 wk of age, and this is followed by tubulointerstitial fibrosis. In this
study, it was hypothesized that circulating TGF-β1 increases renal extracellular matrix …
linked to a full-length porcine transforming growth factor-β1 (TGF-β1) gene has been
described previously. In these mice, transgene expression is limited to the liver and the
plasma level of TGF-β is increased. The earliest renal pathologic change is
glomerulosclerosis, at 3 wk of age, and this is followed by tubulointerstitial fibrosis. In this
study, it was hypothesized that circulating TGF-β1 increases renal extracellular matrix …