Therapeutic prospects for p73 and p63: rising from the shadow of p53
A Vilgelm, W El-Rifai, A Zaika - Drug resistance updates, 2008 - Elsevier
The p53 protein family consists of three transcription factors: p53, p63, and p73. These
proteins share significant structural and functional similarities and each has unique
biological functions as well. Although the role of p53 in cellular stress is extensively studied,
many questions remain about p63 and p73. In this review we summarize current data on
functional interactions within the p53 family, their regulation and roles in response to
genotoxic stress. We also discuss the significance of p73 and p63 for cancer therapy and …
proteins share significant structural and functional similarities and each has unique
biological functions as well. Although the role of p53 in cellular stress is extensively studied,
many questions remain about p63 and p73. In this review we summarize current data on
functional interactions within the p53 family, their regulation and roles in response to
genotoxic stress. We also discuss the significance of p73 and p63 for cancer therapy and …