[HTML][HTML] Oncogenes induce and activate endogenous p73 protein
The identification of upstream pathways that signal to TP73 is crucial for understanding the
biological role of this gene. Since some evidence suggests thatTP73 might play a role in
tumorigenesis, we asked whether oncogenes can induce and activate endogenous TP73.
Here, we show that endogenous p73 α and β proteins are up-regulated in p53-deficient
tumor cells in response to overexpressed E2F1, c-Myc, and E1A. E2F1, c-Myc, and E1A-
mediated p73 up-regulation leads to activation of the p73 transcription function, as shown by …
biological role of this gene. Since some evidence suggests thatTP73 might play a role in
tumorigenesis, we asked whether oncogenes can induce and activate endogenous TP73.
Here, we show that endogenous p73 α and β proteins are up-regulated in p53-deficient
tumor cells in response to overexpressed E2F1, c-Myc, and E1A. E2F1, c-Myc, and E1A-
mediated p73 up-regulation leads to activation of the p73 transcription function, as shown by …