Inhibition of leukotriene synthesis, pharmacokinetics, and tolerability of a novel dietary fatty acid formulation in healthy adult subjects
ME Surette, IL Koumenis, MB Edens, KM Tramposch… - Clinical …, 2003 - Elsevier
Background: Numerous studies have explored dietary-management strategies for
decreasing leukotriene synthesis by inflammatory cells through supplementation with
polyunsaturated fatty acids such as gamma-linolenic acid (GLA) and eicosapentaenoic acid
(EPA). Objectives: This study sought to determine the optimal daily intake, ratios, and
formulation of dietary GLA and EPA required to safely reduce leukotriene biosynthesis in
healthy individuals, and to evaluate the pharmacokinetics and safety profile of such a …
decreasing leukotriene synthesis by inflammatory cells through supplementation with
polyunsaturated fatty acids such as gamma-linolenic acid (GLA) and eicosapentaenoic acid
(EPA). Objectives: This study sought to determine the optimal daily intake, ratios, and
formulation of dietary GLA and EPA required to safely reduce leukotriene biosynthesis in
healthy individuals, and to evaluate the pharmacokinetics and safety profile of such a …