N-acetylcysteine is associated with increased blood loss and blood product utilization during cardiac surgery
DN Wijeysundera, K Karkouti, V Rao… - Critical care …, 2009 - journals.lww.com
Objective: When used to prevent perioperative inflammation and ischemia–reperfusion
injury, N-acetylcysteine may inadvertently impair hemostasis. We, therefore, performed a
post hoc analysis of a recent randomized controlled trial in cardiac surgery to determine
whether N-acetylcysteine was associated with increased blood loss and blood product
transfusion. Design: Blinded (patients, caregivers, outcome assessors) placebo-controlled
parallel group randomized trial (www. ClinicalTrials. gov ID NCT00188630). Setting: Tertiary …
injury, N-acetylcysteine may inadvertently impair hemostasis. We, therefore, performed a
post hoc analysis of a recent randomized controlled trial in cardiac surgery to determine
whether N-acetylcysteine was associated with increased blood loss and blood product
transfusion. Design: Blinded (patients, caregivers, outcome assessors) placebo-controlled
parallel group randomized trial (www. ClinicalTrials. gov ID NCT00188630). Setting: Tertiary …