The in vitro reduction in viscosity of human tracheobronchial secretions by acetylcysteine
AL Sheffner, EM Medler, LW Jacobs… - American Review of …, 1964 - atsjournals.org
AL Sheffner, EM Medler, LW Jacobs, HP Sarett
American Review of Respiratory Disease, 1964•atsjournals.orgIt was recently reported that acetylcysteine (Mucomyst®) markedly reduced the viscosity of
mucoprotein solutions in vitro (1). Clinical studies, in particular those by Webb (2) and Reas
(3), demonstrated the usefulness of this mucolytic agent in the treatment of a variety of
pulmonary disorders. In addition, Kubica and associates (4) found that acetylcysteine rapidly
liquefied sputum for bacteriologic examination. In preparation for the clinical use of
acetylcysteine, a wide variety of in vitro studies, with both human pulmonary secretion and …
mucoprotein solutions in vitro (1). Clinical studies, in particular those by Webb (2) and Reas
(3), demonstrated the usefulness of this mucolytic agent in the treatment of a variety of
pulmonary disorders. In addition, Kubica and associates (4) found that acetylcysteine rapidly
liquefied sputum for bacteriologic examination. In preparation for the clinical use of
acetylcysteine, a wide variety of in vitro studies, with both human pulmonary secretion and …
It was recently reported that acetylcysteine (Mucomyst®) markedly reduced the viscosity of mucoprotein solutions in vitro (1). Clinical studies, in particular those by Webb (2) and Reas (3), demonstrated the usefulness of this mucolytic agent in the treatment of a variety of pulmonary disorders. In addition, Kubica and associates (4) found that acetylcysteine rapidly liquefied sputum for bacteriologic examination.
In preparation for the clinical use of acetylcysteine, a wide variety of in vitro studies, with both human pulmonary secretion and gastric mucin mucoprotein, were conducted to evaluate factors influencing the activity of this mucolytic agent. Information was previously presented describing the action of acetylcysteine in reducing the viscosity of gastric mucin mucoprotein solutions, and showing that the mucolytic activity was due to the sulfhydryl moiety of the compound (1). The present report deals with the mucolytic action of acetylcysteine on human sputum and
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