HAP1 and intracellular trafficking
XJ Li, SH Li - Trends in pharmacological sciences, 2005 - cell.com
XJ Li, SH Li
Trends in pharmacological sciences, 2005•cell.comHuntington's disease is caused by a polyglutamine expansion in the protein huntingtin.
Several studies suggest that huntingtin and its associated protein HAP1 participate in
intracellular trafficking and that polyglutamine expansion affects vesicular transport. A study
now provides new evidence that HAP1 is also involved in the endocytosis of membrane
receptors. These studies offer insight into the normal function of HAP1 and its involvement in
Huntington's disease.
Several studies suggest that huntingtin and its associated protein HAP1 participate in
intracellular trafficking and that polyglutamine expansion affects vesicular transport. A study
now provides new evidence that HAP1 is also involved in the endocytosis of membrane
receptors. These studies offer insight into the normal function of HAP1 and its involvement in
Huntington's disease.
Huntington's disease is caused by a polyglutamine expansion in the protein huntingtin. Several studies suggest that huntingtin and its associated protein HAP1 participate in intracellular trafficking and that polyglutamine expansion affects vesicular transport. A study now provides new evidence that HAP1 is also involved in the endocytosis of membrane receptors. These studies offer insight into the normal function of HAP1 and its involvement in Huntington's disease.
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