Randomized controlled trial of ethyl-eicosapentaenoic acid in Huntington disease: the TREND-HD study

Huntington Study Group TREND-HD … - Archives of …, 2008 - jamanetwork.com
Objective To determine whether ethyl-eicosapentaenoic acid (ethyl-EPA), an ω-3 fatty acid,
improves the motor features of Huntington disease. Design Six-month multicenter,
randomized, double-blind, placebo-controlled trial followed by a 6-month open-label phase
without disclosing initial treatment assignments. Setting Forty-one research sites in the
United States and Canada. Patients Three hundred sixteen adults with Huntington disease,
enriched for a population with shorter trinucleotide (cytosine-adenine-guanine) repeat …