Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes
J Nasir, SB Floresco, JR O'Kusky, VM Diewert… - Cell, 1995 - cell.com
J Nasir, SB Floresco, JR O'Kusky, VM Diewert, JM Richman, J Zeisler, A Borowski, JD Marth…
Cell, 1995•cell.comTargeted Disruption of the Huntington's Disease Gene Results in Embryonic Lethality and
Behavioral and Morphological Changes in Page 1 Cell, Vol. 81,811-823, June 2, 1995,
Copyright © 1995 by Cell Press Targeted Disruption of the Huntington's Disease Gene Results
in Embryonic Lethality and Behavioral and Morphological Changes in Heterozygotes Jamal
Nasir,* Stan B. Floresco,i John R. O'Kusky,t Virginia M. Diewert,§ Joy M. Richman, § Jutta
Zeisler, * II Anita Borowski, ~ Jamey D. Marth, # Anthony G. Phillips, t and Michael R. Hayden*fl …
Behavioral and Morphological Changes in Page 1 Cell, Vol. 81,811-823, June 2, 1995,
Copyright © 1995 by Cell Press Targeted Disruption of the Huntington's Disease Gene Results
in Embryonic Lethality and Behavioral and Morphological Changes in Heterozygotes Jamal
Nasir,* Stan B. Floresco,i John R. O'Kusky,t Virginia M. Diewert,§ Joy M. Richman, § Jutta
Zeisler, * II Anita Borowski, ~ Jamey D. Marth, # Anthony G. Phillips, t and Michael R. Hayden*fl …
Summary
Huntington's disease (HD) is an incurable neuropsychiatric disease associated with CAG repeat expansion within a widely expressed gene that causes selective neuronal death. To understand its normal function, we have created a targeted disruption in exon 5 of Hdh
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