Huntingtin has been reported to regulate the nuclear translocation of the transcriptional
repressor RE1-silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF).
The REST/NRSF-interacting LIM domain protein (RILP) has also been shown to regulate
REST/NRSF nuclear translocation. Therefore, we were prompted to address the question of
how two distinct proteins could have the same function. We initially used a yeast two-hybrid
screen to look for an interaction between huntingtin and RILP. This screen identified …