The effects of modafinil on mood and cognition in Huntington's disease
AD Blackwell, NS Paterson, RA Barker… - …, 2008 - Springer
Psychopharmacology, 2008•Springer
Rationale The wake-promoting agent modafinil selectively improves neuropsychological
task performance in healthy volunteers, in adults with attention deficit hyperactivity disorder
(ADHD) and in schizophrenia. We examined whether modafinil induced similar effects in
individuals with Huntington's disease (HD). Materials and methods Twenty patients with
genetically proven, mild HD participated in a double-blind, randomised, placebo-controlled
cross-over study using a single 200 mg dose of modafinil. Patients undertook a battery of …
task performance in healthy volunteers, in adults with attention deficit hyperactivity disorder
(ADHD) and in schizophrenia. We examined whether modafinil induced similar effects in
individuals with Huntington's disease (HD). Materials and methods Twenty patients with
genetically proven, mild HD participated in a double-blind, randomised, placebo-controlled
cross-over study using a single 200 mg dose of modafinil. Patients undertook a battery of …
Rationale
The wake-promoting agent modafinil selectively improves neuropsychological task performance in healthy volunteers, in adults with attention deficit hyperactivity disorder (ADHD) and in schizophrenia. We examined whether modafinil induced similar effects in individuals with Huntington’s disease (HD).
Materials and methods
Twenty patients with genetically proven, mild HD participated in a double-blind, randomised, placebo-controlled cross-over study using a single 200 mg dose of modafinil. Patients undertook a battery of neuropsychological tests including measures of cognition and mood.
Results
Modafinil increased alertness as indexed by visual analogue scales. Modafinil did not elicit any significant improvements in cognitive function or mood. Modafinil had a deleterious effect on visual recognition and working memory.
Conclusions
Two hundred milligrams acute modafinil administration did improve alertness but did not improve cognition or mood in patients with mild HD. A multiple dose, chronic administration study is needed before the potential clinical utility of modafinil in HD is discounted.
Springer