Huntington's disease (HD) is one of the chronic devastating neurodegenerative disorders.
The pathophysiological processes clearly involve both excitotoxicity and reduced gene
transcription due to the decreased level of histone acetylation, accompanied by the loss of γ-
aminobutyric acidergic (GABAergic) medium-sized spiny neurons in the striatum as a
pathological hallmark of HD. Thus, the antiepileptic drug valproate, which has proved
GABAergic, antiexcitotoxic and histone deacetylase inhibitor effects, might be of value by …